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For the PRR, a given drug-adverse event pair was defined as a signal, if the event count was 3 or more, and the PRR was 2 or more with an associated chi-square value of 4 or more [8], and for the ROR, if the lower limit of the 95% two-sided confidence interval (CI) of ROR exceeded 1 [9]. For the IC, IC025, a criterion indicating the lower limit of the 95% two-sided CI of the IC, was adopted, and an IC025 value exceeding 0 was defined as a signal [10]. Lastly, for the EBGM, an EB05 of 2 or more was set as a threshold for signal detection, where the EB05 is interpreted as the lower one-sided 95% confidence limit of the EBGM [11]. In this study, AERs were extracted for CDDP, CBDCA, and L-OHP, when the signal was detected by either the PRR, ROR, IC or EBGM.. Demographic data, SLE clinical manifestations and treatment, SLE disease activity index (SLEDAI) [12], maternal SLE status (flare or no flare), pregnancy data, its outcome and therapy were recorded from medical charts. Laboratory data included complete blood count, urinalysis, antinuclear antibodies (ANA), anti-Ro/SSA antibodies, anti-La/SSB antibodies, and antiphospholipid antibodies (aPLs). Positive aPLs were defined as more than one presence of anti-cardiolipin Antibodies, β2 glycoprotein, or lupus anticoagulant antibody. The pregnancy outcomes retrieved were live births including term and preterm births, pregnancy loss including miscarriages, stillbirths and neonatal deaths, as well as gestational age at birth in weeks, infant birth weight, delivery mode, lupus flare, oligohydramnios, preterm premature rupture of membrane, IUGR, and pregnancy induced hypertention (PIH), low Apgar score, and congenital anomaly. A flare was defined as onset of new signs of SLE disease activity during pregnancies in patients previously in remission. The criteria for relapse or flare-up of SLE included new evidence of acute synovitis, serositis, pruritis, typical skin lesions, new psychological or neurological symptoms (in the absence of eclampsia), haematological parameter revealing leucopenia, thrombocytopenia or active renal disease during pregnancy. Renal involvement was defined as the following: proteinuria [500 mg/day (in the absence of preeclampsia), cellular casts in urine and dysmorphic hematuria] [13]. SLE flare including renal or CNS involvement and requiring hospitalization for management of flare up was classified as severe type. Premature birth was defined as a live birth occurring before 37 weeks of gestation, stillbirths as no signs of life in a fetus delivered after 24 weeks of gestation, and low birth weight as <2.5 kg birth weight of infant at term. Pregnancy outcomes were compared between SLE patients with and without different characteristics including lupus nephritis, ANA, anti-Ro/SSA antibodies, anti-La/SSB antibodies, aPLs, disease activity at pregnancy and lupus flares during pregnancy.. included 8 replicate pens with 50 birds per pen. The three treatments

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Rarely available to the rental market is this FOUR bedroom TWO STOREY MAISONETTE built to a bespoke design by the original owners and completed in October 2015. Offering spacious living accommodation spread over two levels and situated within close proximity of Saltburn Village and it's amenities including shops, schools, bus, rail routes and just a short stroll to the frequently visited surfing beach.

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